欢迎访问林圣彩实验室主页

103. Asier González, Michael N. Hall, Sheng-Cai Lin, D. Grahame Hardie*. AMPK and TOR: The Yin and Yang of Cellular Nutrient Sensing and Growth Control. Cell Metabolism. 2020 Mar 3; 31(2):472-492. doi.org/10.1016/j.cmet.2020.01.015.

 

102. Chen-Song Zhang, D. Grahame Hardie* and Sheng-Cai Lin*. Glucose Starvation Blocks Translation at Multiple Levels. Cell Metabolism. 2020 Feb 4; 31(2):217-218. doi.org/10.1016/j.cmet.2020.01.005

 

101. Li M#, Zhang CS#, Zong Y#, Feng JW, Ma T, Hu M, Lin Z, Li X, Xie C, Wu Y, Jiang D, Li Y, Zhang C, Tian X, Wang W, Yang Y, Chen J, Cui J, Wu YQ, Chen X, Liu QF, Wu J, Lin SY, Ye Z, Liu Y, Piao HL, Yu L, Zhou Z, Xie XS, Hardie DG, Lin SC*. Transient Receptor Potential V Channels Are Essential for Glucose Sensing by Aldolase and AMPK. Cell Metabolism.2019 Sep 3;30(3):508-524.e12. doi: 10.1016/j.cmet.2019.05.018. Epub 2019 Jun 13.

 

100. Zong Y#, Zhang CS#, Li M#, Wang W#, Wang Z, Hawley SA, Ma T, Feng JW, Tian X, Qi Q, Wu YQ, Zhang C, Ye Z, Lin SY, Piao HL, Hardie DG, Lin SC*. Hierarchical activation of compartmentalized pools of AMPK depends on severity of nutrient or energy stress. Cell Research. 2019 Jun;29(6):460-473. doi: 10.1038/s41422-019-0163-6. Epub 2019 Apr 4.

  

99. Lin SY, Zhang CS, Lin SC*. Carbohydrates: Not All That Bad? Cell Metabolism. 2018 November 6;28:671-672.

  

98. Cai WF#, Zhang C, Wu YQ, Zhuang G, Ye Z, Zhang CS*, Lin SC*. Glutaminase GLS1 senses glutamine availability in a non-enzymatic manner triggering mitochondrial mitochondrial fusion. Cell Reserach. 2018 Jun 22. doi: 10.1038/s41422-018-0057-z.

 

97. Li TY#, Song L#, Sun Y#, Li J#, Yi C, Lam SM, Xu D, Zhou L, Li X, Yang Y, Zhang CS, Xie C, Huang X, Shui G, Lin SY, Reue K, Lin SC*. Tip60-mediated lipin 1 acetylation and ER translocation determine triacylglycerol synthesis rate. Nature Communications. 2018 May 15;9(1):1916. doi: 10.1038/s41467-018-04363-w.

 

96. Luo H#, Jiang M#, Lian G, Liu Q, Shi M, Li TY, Song L, Ye J, He Y, Yao L, Zhang C, Lin ZZ, Zhang CS, Zhao TJ, Jia WP, Li P, Lin SY*, Lin SC*. AIDA Selectively Mediates Downregulation of Fat Synthesis Enzymes by ERAD to Retard Intestinal Fat Absorption and Prevent Obesity. Cell Metabolism. 2018 Apr 3;27(4):843-853.e6. doi: 10.1016/j.cmet. 2018.02.021.

 

95. Sun Y#, Li TY#, Song L#, Zhang C, Li J, Lin ZZ, Lin SC, Lin SY*. Liver-specific deficiency of unc-51 like kinase 1 and 2 protects mice from acetaminophen-induced liver injury. Hepatology. 2018 Jun;67(6):2397-2413. doi: 10.1002/hep. 29759. Epub 2018 Apr 20.

 

94. Lin SC*, Hardie DG*. AMPK: Sensing Glucose as well as Cellular Energy Status. Cell Metabolism.2018 Feb 6;27(2):299-313. doi: 10.1016/j.cmet. 2017.10.009. Epub 2017 Nov 16.

 

93. Zhang CS#, Hawley SA#, Zong Y#, Li M#, Wang Z, Gray A, Ma T, Cui J, Feng JW, Zhu M, Wu YQ, Li TY, Ye Z, Lin SY, Yin H, Piao HL, Hardie DG*, Lin SC*. Fructose-1,6-bisphosphate and aldolase mediate glucose sensing by AMPK. Nature. 2017 Aug 3;548(7665):112-116. doi: 10.1038/nature23275. Epub 2017 Jul 19.

 

92. Zhang CS#, Li M#, Lin SC*. Methods to Study Lysosomal AMPK Activation. Methods Enzymol. 2017;587:465-480. doi: 10.1016/bs.mie. 2016.09.071. Epub 2016 Nov 12.

 

91. Zhang CS#, Li M#, Ma T#, Zong Y, Cui J, Feng JW, Wu YQ, Lin SY, Lin SC*. Metformin Activates AMPK through the Lysosomal Pathway. Cell Metabolism. 2016 Oct 11;24(4):521-522. doi: 10.1016/j.cmet. 2016.09.003.

 

90. Zhang CS#, Lin SC#*. AMPK Promotes Autophagy by Facilitating Mitochondrial Fission. Cell Metabolism. 2016 Mar 8;23(3):399-401. doi: 10.1016/j.cmet. 2016.02.017.

 

89. Liu X, Zhang CS, Lu C, Lin SC, Wu JW, Wang ZX. A conserved motif in JNK/p38-specific MAPK phosphatases as a determinant for JNK1 recognition and inactivation.

Nature Communications. 2016 Mar. 7:10879. doi: 10.1038/ncomms10879.

 

88. Li TY#, Sun Y, Liang Y, Liu Q, Shi Y, Zhang CS, Zhang C, Song L, Zhang P, Zhang X, Li X, Chen T, Huang HY, He X, Wang Y, Wu YQ, Chen S, Jiang M, Chen C, Xie C, Yang JY, Lin Y, Zhao S, Ye Z, Lin SY, Chiu DT, Lin SC*. ULK1/2 Constitute a Bifurcate Node Controlling Glucose Metabolic Fluxes in Addition to Autophagy. Moleculer Cell. 2016 May 5;62(3):359-370. doi: 10.1016/j.molcel. 2016.04.009.

 

87. Zhang CS#, Liu Q#, Li M#, Lin SY#, Peng Y, Wu D, Li TY, Fu Q, Jia W, Wang X, Ma T, Zong Y, Cui J, Pu C, Lian G, Guo H, Ye Z, Lin SC*. RHOBTB3 promotes proteasomal degradation of HIFalpha through facilitating hydroxylation and suppresses the Warburg effect. Cell Research. 2015 Sep;25(9):1025-42. doi: 10.1038/cr. 2015.90. Epub 2015 Jul 28.

 

86. Zheng LS#, Liu YT, Chen L, Wang Y, Rui YN, Huang HZ, Lin SY, Wang J, Wang ZX, Lin SC, Wu JW. Structure and mechanism of the unique C2 domain of Aida. FEBS Journal. 2014 Oct;281(20):4622-32. doi: 10.1111/febs.12966. Epub 2014 Sep 6.

 

85. Zhang CS#, Jiang B#, Li M#, Zhu M, Peng Y, Zhang YL, Wu YQ, Li TY, Liang Y, Lu Z, Lian G, Liu Q, Guo H, Yin Z, Ye Z, Han J, Wu JW, Yin H, Lin SY, Lin SC*. The lysosomal v-ATPase-Ragulator complex is a common activator for AMPK and mTORC1, acting as a switch between catabolism and anabolism. Cell Metabolism. 2014 Sep 2;20(3):526-40. doi: 10.1016/j.cmet. 2014.06.014. Epub 2014 Jul 4

 

84. Zhang YL#, Guo H#, Zhang CS#, Lin SY, Yin Z, Peng Y, Luo H, Shi Y, Lian G, Zhang C, Li M, Ye Z, Ye J, Han J, Li P, Wu JW, Lin SC*. AMP as a low-energy charge signal autonomously initiates assembly of AXIN-AMPK-LKB1 complex for AMPK activation. Cell Metabolism. 2013 Oct 1;18(4):546-55. doi: 10.1016/j.cmet. 2013.09.005.

 

83. Li TY#, Lin SY, Lin SC*. Mechanism and physiological significance of growth factor-related autophagy. Physiology (Bethesda). 2013 Nov;28(6):423-31. doi: 10.1152/physiol.00023. 2013.

 

82. He Y#, Lian G, Lin SC, Ye Z, Li Q*. MDM2 Inhibits Axin-Induced p53 Activation Independently of its E3 Ligase Activity. PLoS One. 2013 Jun 27;8(6):e67529. doi: 10.1371/journal.pone.0067529. Print 2013.

 

81. Ruan K#, Ye F#, Li C#, Liou YC, Lin SC, Lin SY*. PLK1 interacts and phosphorylates Axin that is essential for proper centrosome formation. Plos One. 2012;7(11):e49184. doi: 10.1371/journal.pone.0049184. Epub 2012 Nov 14.

 

80. Zhan YY#, Chen Y#, Zhang Q#, Zhuang JJ, Tian M, Chen HZ, Zhang LR, Zhang HK, He JP, Wang WJ, Wu R, Wang Y, Shi C, Yang K, Li AZ, Xin YZ, Li TY, Yang JY, Zheng ZH, Yu CD, Lin SC, Chang C, Huang PQ, Lin T*, Wu Q*. The orphan nuclear receptor Nur77 regulates LKB1 localization and activates AMPK. Nature Chemical Biology. 2012 Nov;8(11):897-904. doi: 10.1038/nchembio.1069. Epub 2012 Sep 16.

 

79. Guo HL#, Zhang C#, Liu Q#, Li Q, Lian G, Wu D, Li X, Zhang W, Shen Y, Ye Z, Lin SY, Lin SC*. The Axin/TNKS complex interacts with KIF3A and is required for insulin-stimulated GLUT4 translocation. Cell Research. 2012 Aug;22(8):1246-57. doi: 10.1038/cr. 2012.52. Epub 2012 Apr 3.

 

78. Lin SY#, Li TY#, Liu Q, Zhang C, Li X, Chen Y, Zhang SM, Lian G, Liu Q, Ruan K, Wang Z, Zhang CS, Chien KY, Wu J, Li Q, Han J, Lin SC*. Protein phosphorylation-acetylation cascade connects growth factor deprivation to autophagy. Autophagy. 2012 Sep;8(9):1385-6. doi: 10.4161/auto. 20959. Epub 2012 Jun 21.

 

77. Lin SY#, Li TY#, Liu Q, Zhang C, Li X, Chen Y, Zhang SM, Lian G, Liu Q, Ruan K, Wang Z, Zhang CS, Chien KY, Wu J, Li Q, Han J, Lin SC*. GSK3-TIP60-ULK1 signaling pathway links growth factor deprivation to autophagy. Science. 2012 Apr 27;336(6080):477-81. doi: 10.1126/science.1217032.

 

76. Zhang M#, Zhang J#, Lin SC, Meng A*. β-Catenin 1 and β-catenin 2 play similar and distinct roles in left-right asymmetric development of zebrafish embryos. Development. 2012 Jun;139(11):2009-19. doi: 10.1242/dev.074435. Epub 2012 Apr 25.

 

75. Lin SC#, Han Y#, Shi Y, Rong H, Zheng S, Jin S, Lin SY, Lin SC*, Li Y*. Revealing a steroid receptor ligand as a unique PPARγ agonist. Cell Research. 2012 Apr;22(4):746-56. doi: 10.1038/cr. 2011.162. Epub 2011 Oct 11.

 

74. Fang WQ#, Ip JP, Li R, Ng YP, Lin SC, Chen Y, Fu AK, Ip NY*. Cdk5-mediated phosphorylation of Axin directs axon formation during cerebral cortex development. Journal of Neuroscience. 2011 Sep 21;31(38):13613-24. doi: 10.1523/JNEUROSCI.3120-11. 2011.

 

73. Chen HZ#, Liu QF, Li L, Wang WJ, Yao LM, Yang M, Liu B, Chen W, Zhan YY, Zhang MQ, Cai JC, Zheng ZH, Lin SC, Li BA*, Wu Q*. The orphan receptor TR3 suppresses intestinal tumorigenesis in mice by downregulating Wnt signalling. Gut. 2012 May;61(5):714-24. doi: 10.1136/gutjnl-2011-300783. Epub 2011 Aug 28.

 

72. Liu YT#, Dan QJ, Wang J, Feng Y, Chen L, Liang J, Li Q, Lin SC, Wang ZX, Wu JW*. Molecular basis of Wnt activation via the DIX domain protein Ccd1. Journal of Biological Chemistry. 2011 Mar 11;286(10):8597-608. doi: 10.1074/jbc.M110.186742. Epub 2010 Dec 28.

 

71. Zheng M#, Wang YH, Wu XN, Wu SQ, Lu BJ, Dong MQ, Zhang H, Sun P, Lin SC, Guan KL, Han J*. Inactivation of Rheb by PRAK-mediated phosphorylation is essential for energy-depletion-induced suppression of mTORC1. Nature Cell Biology. 2011 Mar;13(3):263-72. doi: 10.1038/ncb2168. Epub 2011 Feb 20.

 

70. Li Q#, He Y#, Wei L, Wu X, Wu D, Lin S, Wang Z, Ye Z, Lin SC*. AXIN is an essential co-activator for the promyelocytic leukemia protein in p53 activation. Oncogene. 2011 Mar 10;30(10):1194-204. doi: 10.1038/onc. 2010.499. Epub 2010 Nov 8.

 

69. Zhou YT#, Chew LL, Lin SC, Low BC*. The BNIP-2 and Cdc42GAP homology (BCH) domain of p50RhoGAP/Cdc42GAP sequesters RhoA from inactivation by the adjacent GTPase-activating protein domain. Molecular Biology of the Cell. 2010 Sep 15;21(18):3232-46. doi: 10.1091/mbc.E09-05-0408. Epub 2010 Jul 21.

 

68. Quyun C#, Ye Z, Lin SC, Lin B*. Recent patents and advances in genomic biomarker discovery for colorectal cancers. Recent Patens of DNA & Gene Sequences. 2010 Jun;4(2):86-93.

 

67. Fang X#, Yu W, Li L, Shao J, Zhao N, Chen Q, Ye Z, Lin SC, Zheng S, Lin B*. ChIP-seq and functional analysis of the SOX2 gene in colorectal cancers. OMICS. 2010 Aug;14(4):369-84. doi: 10.1089/omi. 2010.0053.

 

66. Cheng Y#, Wang J, Shao J, Chen Q, Mo F, Ma L, Han X, Zhang J, Chen C, Zhang C, Lin S, Yu J, Zheng S, Lin SC*, Lin B*. Identification of novel SNPs by next-generation sequencing of the genomic region containing the APC gene in colorectal cancer patients in China. Omics-a Journal of Integrative Biology. 2010 Jun;14(3):315-25. doi: 10.1089/omi. 2010.0018.

 

65. Ha SD#, Ham B, Mogridge J, Saftig P, Lin SC, Kim SO*. Cathepsin B-mediated autophagy flux facilitates the anthrax toxin receptor 2-mediated delivery of anthrax lethal factor into the cytoplasm. Journal of Biological Chemistry. 2010 Jan 15;285(3):2120-9. doi: 10.1074/jbc.M109.065813. Epub 2009 Oct 26.

 

64. Yan D#, Wu Y#, Feng Y, Lin SC, Lin X*. The core protein of glypican Dally-like determines its biphasic activity in wingless morphogen signaling. Developmental Cell. 2009 Oct;17(4):470-81. doi: 10.1016/j.devcel. 2009.09.001.

 

63. Li Q#, Lin S, Wang X, Lian G, Lu Z, Guo H, Ruan K, Wang Y, Ye Z, Han J, Lin SC*. Axin determines cell fate by controlling the p53 activation threshold after DNA damage. Nature Cell Biology.2009 Sep;11(9):1128-34.

 

62. Zhang DW#, Shao J, Lin J, Zhang N, Lu BJ, Lin SC, Dong MQ, Han J*. RIP3, an energy metabolism regulator that switches TNF-induced cell death from apoptosis to necrosis. Science. 2009 Jul 17;325(5938):332-6. doi: 10.1126/science.1172308. Epub 2009 Jun 4.

 

61. Zhang Y#, Li X, Qi J, Wang J, Liu X, Zhang H, Lin SC, Meng A*. Rock2 controls TGFbeta signaling and inhibits mesoderm induction in zebrafish embryos. Journal of Cell Science. 2009 Jul 1;122(Pt 13):2197-207. doi: 10.1242/jcs.040659. Epub 2009 Jun 9.

 

60. Zhan Y#, Du X#, Chen H, Liu J, Zhao B, Huang D, Li G, Xu Q, Zhang M, Weimer BC, Chen D, Cheng Z, Zhang L, Li Q, Li S, Zheng Z, Song S, Huang Y, Ye Z, Su W, Lin SC*, Shen Y*, Wu Q*. Cytosporone B is an agonist for nuclear orphan receptor Nur77. Nature Chemical Biology. 2008 Sep;4(9):548-56. doi: 10.1038/nchembio.106.

 

59. Lu Z#, Liu W#, Huang H#, He Y, Han Y, Rui Y, Wang Y, Li Q, Ruan K, Ye Z, Low BC, Meng A, Lin SC*. Protein encoded by the Axin(Fu) allele effectively down-regulates Wnt signaling but exerts a dominant negative effect on c-Jun N-terminal kinase signaling. Journal of Biological Chemistry. 2008 May 9;283(19):13132-9. doi: 10.1074/jbc.M710595200. Epub 2008 Mar 3.

 

58. Li Q#, Zhang N#, Zhang D, Wang Y, Lin T, Wang Y, Zhou H, Ye Z, Zhang F, Lin SC, Han J*. Determinants that control the distinct subcellular localization of p38alpha-PRAK and p38beta-PRAK complexes. Journal of Biological Chemistry.2008 Apr 18;283(16):11014-23. doi: 10.1074/jbc.M709682200. Epub 2008 Feb 11.

 

57. Lin SY#, Wang J, Ye Z, Ip NY, Lin SC*. CDK5 activator p35 downregulates E-cadherin precursor independently of CDK5. FEBS Letters. 2008 Apr 9;582(8):1197-202. doi: 10.1016/j.febslet. 2008.02.053. Epub 2008 Mar 4.

 

56. Yang Z#, Cheng W, Hong L, Chen W, Wang Y, Lin SC, Han J, Zhou H*, Gu J*. Adenine nucleotide (ADP/ATP) translocase 3 participates in the tumor necrosis factor induced apoptosis of MCF-7 cells. Molecular Biology of the Cell. 2007 Nov;18(11):4681-9. Epub 2007 Sep 12.

 

55. Ryo A#, Hirai A, Nishi M, Liou YC, Perrem K, Lin SC, Hirano H, Lee SW, Aoki I*. A suppressive role of the prolyl isomerase Pin1 in cellular apoptosis mediated by the death-associated protein Daxx. Journal of Biological Chemistry. 2007 Dec 14;282(50):36671-81. Epub 2007 Oct 15.

 

54. Chan SC#, Lin SC, Li P*. Regulation of Cidea protein stability by the ubiquitin-mediated proteasomal degradation pathway. Biochemical Journal. 2007 Dec 1;408(2):259-66.

 

53. Rui Y#, Xu Z#, Xiong B#, Cao Y#, Lin S, Zhang M, Chan SC, Luo W, Han Y, Lu Z, Ye Z, Zhou HM, Han J, Meng A*, Lin SC*. A beta-catenin-independent dorsalization pathway activated by Axin/JNK signaling and antagonized by aida. Developmental Cell. 2007 Aug;13(2):268-82.

 

52. Lin SC#, Li Q. Axin bridges Daxx to p53. Cell Research. 2007 Apr;17(4):301-2.

 

51. Zou H#, Li Q, Lin SC, Wu Z, Han J, Ye Z*. Differential requirement of MKK4 and MKK7 in JNK activation by distinct scaffold proteins. FEBS Letters. 2007 Jan 23;581(2):196-202. Epub 2006 Dec 14.

 

50. Li Q#, Wang X, Wu X, Rui Y, Liu W, Wang J, Wang X, Liou YC, Ye Z, Lin SC*. Daxx cooperates with the Axin/HIPK2/p53 complex to induce cell death. Cancer Research. 2007 Jan 1;67(1):66-74.

 

49. Zhao BX#, Chen HZ, Lei NZ, Li GD, Zhao WX, Zhan YY, Liu B, Lin SC, Wu Q*. p53 mediates the negative regulation of MDM2 by orphan receptor TR3. The EMBO Journal. 2006 Dec 13;25(24):5703-15. Epub 2006 Nov 30.

 

48. Xiong B#, Rui Y, Zhang M, Shi K, Jia S, Tian T, Yin K, Huang H, Lin S, Zhao X, Chen Y, Chen YG, Lin SC*, Meng A*. Tob1 controls dorsal development of zebrafish embryos by antagonizing maternal beta-catenin transcriptional activity. Developmental Cell. 2006 Aug;11(2):225-38.

 

47. Liu W#, Rui H, Wang J, Lin S, He Y, Chen M, Li Q, Ye Z, Zhang S, Chan SC, Chen YG, Han J, Lin SC*. Axin is a scaffold protein in TGF-beta signaling that promotes degradation of Smad7 by Arkadia. The EMBO Journal. 2006 Apr 19;25(8):1646-58. Epub 2006 Apr 6.

 

46. Zhou H#, Zheng M, Chen J, Xie C, Kolatkar AR, Zarubin T, Ye Z, Akella R, Lin SC, Goldsmith EJ, Han J*. Determinants that control the specific interactions between TAB1 and p38alpha. Molecular and Cellular Biology. 2006 May;26(10):3824-34.

 

45. Xie C#, Zhang N, Zhou H, Li J, Li Q, Zarubin T, Lin SC, Han J*. Distinct roles of basal steady-state and induced H-ferritin in tumor necrosis factor-induced death in L929 cells. Molecular and Cellular Biology. 2005 Aug;25(15):6673-81.

 

44. Zhou H#, Zarubin T, Ji Z, Min Z, Zhu W, Downey JS, Lin SC, Han J*. Frequency and distribution of AP-1 sites in the human genome. DNA Research. 2005;12(2):139-50.

 

43. Jing Q#, Huang S, Guth S, Zarubin T, Motoyama A, Chen J, Di Padova F, Lin SC, Gram H, Han J*. Involvement of microRNA in AU-rich element-mediated mRNA instability. Cell. 2005 Mar 11;120(5):623-34.

 

42. Luo W#, Zou H, Jin L, Lin S, Li Q, Ye Z, Rui H, Lin SC*. Axin contains three separable domains that confer intramolecular, homodimeric, and heterodimeric interactions involved in distinct functions. Journal of Biological Chemistry. 2005 Feb 11;280(6):5054-60. Epub 2004 Dec 5.

 

41. Rui Y#, Xu Z#, Lin S, Li Q, Rui H, Luo W, Zhou HM, Cheung PY, Wu Z, Ye Z, Li P, Han J, Lin SC*. Axin stimulates p53 functions by activation of HIPK2 kinase through multimeric complex formation. EMBO Journal. 2004 Nov 24;23(23):4583-94. Epub 2004 Nov 4.

 

40. Cheung PY#, Zhang Y, Long J, Lin SC, Zhang M, Jiang Y, Wu Z*. p150(Glued), Dynein, and microtubules are specifically required for activation of MKK3/6 and p38 MAPKs. Journal of Biological Chemistry.2004 Oct 29;279(44):45308-11. Epub 2004 Sep 16.

 

39. Li J#Li Q#Xie CZhou HWang YZhang NShao HChan SCPeng XLin SCHan J*. Beta-actin is required for mitochondria clustering and ROS generation in TNF-induced, caspase-independent cell death. Journal of Cell Science.2004 Sep 15;117(Pt 20):4673-80.

 

38. Lin SC#, Li P*. CIDE-A, a novel link between brown adipose tissue and obesity. Trends in Molecular Medicine. 2004; 10: 434-439 2004 Sep;10(9):434-9.

 

37. Lin XF#, Zhao BX#, Chen HZ, Ye XF, Yang CY, Zhou HY, Zhang MQ, Lin SC, Wu Q*. RXRalpha acts as a carrier for TR3 nuclear export in a 9-cis retinoic acid-dependent manner in gastric cancer cells. Journal of Cell Science. 2004 Nov 1;117(Pt 23):5609-21. Epub 2004 Oct 19.

 

36. Wong CK#, Luo W, Deng Y, Zou H, Ye Z, Lin SC*. The DIX domain protein coiled-coil-DIX1 inhibits c-Jun N-terminal kinase activation by Axin and dishevelled through distinct mechanisms. Journal of Biological Chemistry. 2004 Sep 17;279(38):39366-73. Epub 2004 Jul 15.

 

35. Luo W*, Lin SC*. Axin: a master scaffold for multiple signaling pathways. Neurosignals.2004 May-Jun;13(3):99-113.

 

34. Jin LH#, Shao QJ, Luo W, Ye ZY, Li Q, Lin SC*. Detection of point mutations of the Axin1 gene in colorectal cancers. International Journal of Cancer. 2003 Dec 10;107(5):696-9.

 

33. Zhou ZH#, Yon Toh S#, Chen Z#, Guo K, Ng CP, Ponniah S, Lin SC, Hong W, Li P*. Cidea-deficient mice have lean phenotype and are resistant to obesity.Nature Genetics. 2003 Sep;35(1):49-56. Epub 2003 Aug 10.

 

32. Luo W#, Ng WW, Jin LH, Ye Z, Han J, Lin SC*. Axin utilizes distinct regions for competitive MEKK1 and MEKK4 binding and JNK activation. Journal of Biological Chemistry. 2003 Sep 26;278(39):37451-8. Epub 2003 Jul 23.

 

31. Xu Z#, Lai KO, Zhou HM, Lin SC*, Ip NY*. Ephrin-B1 reverse signaling activates JNK through a novel mechanism that is independent of tyrosine phosphorylation. Journal of Biological Chemistry. 2003 Jul 4;278(27):24767-75. Epub 2003 Apr 22.

 

30. Stoothoff WH#, Bailey CD, Mi K, Lin SC, Johnson GV*. Axin negatively affects tau phosphorylation by glycogen synthase kinase 3beta. Journal of Neurochemistry. 2002 Nov;83(4):904-13.

 

29. Rui HL#, Fan E, Zhou HM, Xu Z, Zhang Y, Lin SC*. SUMO-1 modification of the C-terminal KVEKVD of Axin is required for JNK activation but has no effect on Wnt signaling. Journal of Biological Chemistry. 2002 Nov 8;277(45):42981-6. Epub 2002 Sep 9.

 

28. Zhang Y#, Qiu WJ, Chan SC, Han J, He X, Lin SC*. Casein kinase I and casein kinase II differentially regulate axin function in Wnt and JNK pathways. Journal of Biological Chemistry. 2002 May 17;277(20):17706-12. Epub 2002 Mar 7.

 

27. Chen C#, Wang H, Fong CW, Lin SC*. Multiple phosphorylation sites in RGS16 differentially modulate its GAP activity. FEBS Letters. 2001 Aug 24;504(1-2):16-22.

 

26. Wang X#, Ono K, Kim SO, Kravchenko V, Lin SC, Han J*. Metaxin is required for tumor necrosis factor-induced cell death. EMBO Report. 2001 Jul;2(7):628-33. Epub 2001 Jul 3.

 

25. Zhang Y#, Qiu WJ, Liu DX, Neo SY, He X, Lin SC*. Differential molecular assemblies underlie the dual function of Axin in modulating the WNT and JNK pathways. Journal of Biological Chemistry. 2001 Aug 24;276(34):32152-9. Epub 2001 Jun 14.

 

24. Fong CW#, Zhang Y, Neo SY, Lin SC*. Specific induction of RGS16 (regulator of G-protein signalling 16) mRNA by protein kinase C in CEM leukaemia cells is mediated via tumour necrosis factor alpha in a calcium-sensitive manner. Biochemical Journal. 2000 Dec 15;352 Pt 3:747-53.

 

23. Neo SY#, Zhang Y#, Yaw LP, Li P, Lin SC*. Axin-induced apoptosis depends on the extent of its JNK activation and its ability to down-regulate beta-catenin levels. Biochemical and Biophysical Research Communications.2000 May 27;272(1):144-50.

 

22. Zhang Y#, Neo SY, Han J, Lin SC*. Dimerization choices control the ability of axin and dishevelled to activate c-Jun N-terminal kinase/stress-activated protein kinase. Journal of Biological Chemistry. 2000 Aug 11;275(32):25008-14.

 

21. Zhang Y#, Neo SY, Wang X, Han J, Lin SC*. Axin forms a complex with MEKK1 and activates c-Jun NH(2)-terminal kinase/stress-activated protein kinase through domains distinct from Wnt signaling. Journal of Biological Chemistry.1999 Dec 3;274(49):35247-54.

 

20. Chen C#, Seow KT, Guo K, Yaw LP, Lin SC*. The membrane association domain of RGS16 contains unique amphipathic features that are conserved in RGS4 and RGS5. Journal of Biological Chemistry. 1999 Jul 9;274(28):19799-806.

 

19. Zhang Y#, Neo SY, Han J, Yaw LP, Lin SC*. RGS16 attenuates galphaq-dependent p38 mitogen-activated protein kinase activation by platelet-activating factor. Journal of Biological Chemistry. 1999 Jan 29;274(5):2851-7.

 

18. Chen C#, Lin SC*. The core domain of RGS16 retains G-protein binding and GAP activity in vitro, but is not functional in vivo. FEBS Letters. 1998 Feb 6;422(3):359-62.

 

17. Zhang Y#, Lin SC*. Molecular characterization of the cyclin-dependent kinase inhibitor p27 promoter. Biochimica et Biophysica Acta. 1997 Sep 12;1353(3):307-17.

 

16. Huang S#, Jiang Y, Li Z, Nishida E, Mathias P, Lin SC, Ulevitch RJ, Nemerow GR, Han J*. Apoptosis signaling pathway in T cells is composed of ICE/Ced-3 family proteases and MAP kinase kinase 6b. Immunity. 1997 Jun;6(6):739-49.

 

15. Chen C#, Zheng B, Han J, Lin SC*. Characterization of a novel mammalian RGS protein that binds to Galpha proteins and inhibits pheromone signaling in yeast. Journal of Biological Chemistry. 1997 Mar 28;272(13):8679-85.

 

14. Han J*, Wang X, Jiang Y, Ulevitch RJ, Lin SC. Identification and characterization of a predominant isoform of human MKK3. FEBS Letters. 1997 Feb 10;403(1):19-22.

 

13. Rosenfeld MG#, Bach I, Erkman L, Li P, Lin C, Lin SC, McEvilly R, Ryan A, Rhodes S, Schonnemann M, Scully K*. Transcriptional control of cell phenotypes in the neuroendocrine system. Recent Progress in Hormone Research. 1996;51:217-38; discussion 238-9.

 

12. Jiang Y#,Chen C, Li Z, Guo W, Gegner JA, Lin SC, HanJ*. Characterization of the structure and function of a new mitogen-activated protein kinase (p38beta). Journal of Biological Chemistry.1996 Jul 26;271(30):17920-6.

 

11. Kamei Y#, Xu L, Heinzel T, Torchia J, Kurokawa R, Gloss B, Lin SC, Heyman RA, Rose DW, Glass CK, Rosenfeld MG*. A CBP integrator complex mediates transcriptional activation and AP-1 inhibition by nuclear receptors. Cell.1996 May 3;85(3):403-14.

 

10. Andersen B#, Pearse RV, Jenne K, Sornson M, Lin SC, Bartke A, Rosenfeld MG*. The Ames dwarf gene is required for Pit-1 gene activation. Developmental Biology. 1995 Dec;172(2):495-503.

 

9. Lin SC#, Li S, Drolet DW, Rosenfeld MG*. Pituitary ontogeny of the Snell dwarf mouse reveals Pit-1-independent and Pit-1-dependent origins of the thyrotrope. Development.1994 Mar;120(3):515-22.

 

8. Yu FX#, Lin SC, Morrison-Bogorad M, Yin HL*. Effects of thymosin beta 4 and thymosin beta 10 on actin structures in living cells. Cell Motility Cytoskeleton.1994;27(1):13-25.

 

7. Lin SC#, Lin CR, Gukovsky I, Lusis AJ, Sawchenko PE, Rosenfeld MG*. Molecular basis of the little mouse phenotype and implications for cell type-specific growth. Nature. 1993 Jul 15;364(6434):208-13.

 

6. Rhodes SJ#, Chen R, DiMattia GE, Scully KM, Kalla KA, Lin SC, Yu VC, Rosenfeld MG*. A tissue-specific enhancer confers Pit-1-dependent morphogen inducibility and autoregulation on the pit-1 gene. Gene Development.1993 Jun;7(6):913-32.

 

5. Border BG#, Lin SC, Griffin WS, Pardue S, Morrison-Bogorad M*. Alterations in actin-binding beta-thymosin expression accompany neuronal differentiation and migration in rat cerebellum.  Journal of Neurochemistry. 1993 Dec;61(6):2104-14.

 

4. Yu FX#, Lin SC, Morrison-Bogorad M, Atkinson MA, Yin HL*. Thymosin beta 10 and thymosin beta 4 are both actin monomer sequestering proteins. Journal of Biological Chemistry. 1993 Jan 5;268(1):502-9.

 

3. Lin CJ#, Lin SC, Chang CP, Rosenfeld MG*. Pit-1-dependent expression of the receptor for growth hormone releasing factor mediates pituitary cell growth. Nature.1992 Dec 24-31;360(6406):765-8.

 

2. Lin SC#, Morrison-Bogorad M*. Cloning and characterization of a testis-specific thymosin beta 10 cDNA. Expression in post-meiotic male germ cells. Journal of Biological Chemistry. 1991 Dec 15;266(34):23347-53.

 

1. Lin SC#, Morrison-Bogorad M*. Developmental expression of mRNAs encoding thymosins beta 4 and beta 10 in rat brain and other tissues. Journal of Molecular Neuroscience.1990;2(1):35-44.